任丽娟,张方圆,李春芳,姚庆强,王凯

• 1:山东第一医科大学(山东省医学科学院)药学院(药物研究所)

摘要(Abstract)：

葡萄糖探针的开发是分子识别领域的研究热点。生物体内异常的葡萄糖变化往往与代谢性疾病的发生和发展密切相关，包括糖尿病、肥胖、恶性肿瘤及神经退行性疾病等。因此，寻找简单、有效的葡萄糖探针对相关代谢性疾病的诊断和治疗具有重大意义。硼酸类化合物能够迅速与葡萄糖等糖类物质中1,2-或1,3-二羟基可逆性结合，这一特性使其成为识别葡萄糖的理想分子探针。此外，硼酸类探针具备合成简便、稳定性好、灵敏度高、分析速度快等优点。本文首先阐述了硼酸与葡萄糖的识别机理，并对近年来基于硼酸类的葡萄糖探针研究进行了归纳和总结，包括荧光探针、电化学探针、凝胶探针和光子晶体探针等。通过比较不同类型探针的检测原理和性能，深入探讨了各自的优缺点。还重点探讨了硼酸葡萄糖传感策略在未来面临的挑战与机遇，并从连续血糖监测及复杂生物体系中葡萄糖的实时动态监测两方面展望了硼酸类葡萄糖探针的应用前景。

关键词(KeyWords)： 硼酸;探针;葡萄糖检测;荧光;电化学

Abstract:

Keywords:

基金项目(Foundation): 山东省自然科学基金资助项目（ZR2023QB181）;; 山东第一医科大学高层次人才引进经费资助项目（2025-2029）

作者(Author): 任丽娟,张方圆,李春芳,姚庆强,王凯

DOI: 10.14002/j.hxya.2025.04.011

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